Amid many years of research aimed at understanding the progression of neurodegenerative diseases, such as Alzheimer’s disease, no cure or treatment exists.
In the Journal of Molecular Neuroscience, researchers associated with Carnegie Mellon University have determined through their new data that past efforts to establish an effective treatment for Alzheimer’s disease have been doomed due to a mistake.
“Based on our findings, Alzheimer’s disease requires a similar approach to treating HIV, where you have a cocktail of drugs used to treat different elements of the disease,” said a study author.
“Together, these drugs work toward a larger goal; treat the symptoms of Alzheimer’s disease in a particular patient.
According to author Liqing Song and colleagues: “Our study shows that monomeric tau protein is rapidly endocytosed by several CNS-relevant cell lines, and the fastest rate of tau endocytosis was observed in glial cells among all the cell types tested.”
“This study demonstrates the important role of HSPGs and LRP1 in regulating cellular immune responses to tau monomers, providing a novel target to attenuate the neuroinflammatory environment prior to the formation of neurofibrillary tangles.”